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Longevity

Longevity science, biological aging, healthspan, geroscience, and interventions targeting the mechanisms of aging.

5 published reports
LongevityBrain & Cognition

Study Links Oligodendrocyte NRF2 Changes to Cognitive Decline in Aging Mice

Research examining aging-related white matter changes in humans and mice linked poorer cognitive trajectories with altered oligodendrocyte behavior, including reduced NRF2 activity. In aged mice, selectively removing NRF2 from oligodendrocytes was associated with less cognitive improvement and changes resembling those observed in human cognitive decline, although the findings do not establish a treatment for preserving cognition.

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LongevityResearch

Analysis Finds Some Epigenetic Aging Clocks Respond More Consistently to Interventions

An analysis of 51 longitudinal intervention studies found that epigenetic clocks designed to predict mortality or the pace of aging showed the most consistent responses across interventions. The findings suggest these measures may be useful for designing future trials, but they do not yet establish any clock as a validated surrogate for aging or longevity outcomes.

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Longevity

Mistranslation Mutations Extend Lifespan in Reproducing Female Flies

A study in Drosophila melanogaster found that two forms of RNA-to-protein mistranslation were associated with longer lifespans in mated female flies. The effect was not explained by lower egg-laying or fertilization rates, challenging the expectation that reproduction would make the cellular stress of mistranslation more harmful.

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LongevityBrain & Cognition

Senolytic Strategies Rejuvenate Microglia in the White Matter of Aged Mice

A study in naturally aged mice found that pharmacological and pharmacogenetic senotherapeutic approaches reduced a senescent, disease-associated microglial population in a region of brain white matter. The interventions were linked with a more youthful microglial organization, but the findings remain preclinical and do not establish a benefit in humans.

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LongevityResearch

Mouse ALS Study Points to Mertk-Linked Microglial Killing of Motor Neurons

Research in the SOD1G93A mouse model of ALS found that disabling Axl and Mertk in microglia was associated with longer lifespan and preservation of certain motor neurons and neuromuscular synapses. The findings suggest microglia may engulf living neurons, but whether the mechanism applies to human ALS remains unresolved.

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